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To ensure a systematic and transparent literature acquisition process, a standardized search strategy was applied across major academic databases, including PubMed, Embase, Web of Science Core Collection, and Cochrane Library

6 Shared mechanisms of resistance in CRC While the modalities of colorectal cancer treatment each confer their own mechanisms of resistance, there are multiple shared pathways between treatment options that work in tandem to confer therapeutic resistance ( Figure 2 )

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease

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