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Description

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD(+)/SIRT inactivation

Kayano et al., 2018

Purpura M, Lowery RP, Wilson JM, Mannan H, Mnch G, Razmovski-Naumovski V

Further investigation on signal transduction pathways among the three major pancreatic endocrine cell types demonstrated that the probability of interaction between key regulators of glucagon secretion, such as ligand-receptor pairs Sst-Sstr2 , Sst-Sstr3 , Ins1-Insr , and Ins2-Insr , were significantly reduced in GCGR-KO cells (Fig