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To investigate mitochondrial membrane potential, 200 l of loaded synaptosomes were added to the cuvette containing 1.8 ml of incubation medium B

Farnesyltransferase inhibitors reverse the proliferative phenotype in Nf1 -deficient mouse cells, and can reverse spatial learning impairments in a mouse model of NF1 , by decreasing RAS levels.6 These observations have prompted investigations into the use of farnesyltransferase inhibitors for the treatment of NF-1-related complications, such as rapidly growing plexiform neurofibromas