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Mechanisms of intergenerational transmission of polycystic ovary syndrome

H 2 O 2 signaling leads to the release of Nrf2 from complexes with Kelch-like ECH-associated protein 1 (Keap1) and ubiquitin ligase Cullin 3 and into the nucleus, where it binds to antioxidant response elements (ARE) and activates the expression of its target gene GPX8, which in turn regulates the expression of ER calcium by regulating SERCA (Granatiero et al., 2019)

Given this limitation, dose escalation strategies may be necessary, which could lead to an increased risk of serious side effects

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N-Acetyl Cysteine (NAC) The Glutathione Precursor NAC provides cysteine the rate-limiting amino acid in glutathione production