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The physiologic basis of this impairment is, however, unclear

People with MS usually present at an earlier age than those with neurogenerative disorders, possibly because their genetic propensity to autoimmunity (2) makes them susceptible early in life to the autoimmune effects of toxic metals (98)

SHMT1 inhibits the translation of SHMT2 by directly binding to the 5UTR (UTR2) of the SHMT2 transcript

McCarthy originally felt that it was difficult to improve upon the song's demo version, but once the quartet recorded the studio version, said "it is one of those songs that when you hear it you cannot help but get into it, totally"

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