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In summary, while systemic IV DFO is invasive and non-specific for brain delivery for chronic brain iron overload, it may have potential applications for immediate effect and is useful in acute neurological damage where iron is rapidly released and accessible (e.g., acute iron poisoning or ICH)

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This condition of IGF-I deficiency highlight the critical role of IGF-I on brain development and function, as also will be stated in section Neurodegenerative diseases