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Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig

Metformins mechanism of action is still being explored and remains a debated theory [22]

Even if a molecule is affected by irradiation, and thus undergoes the process of direct photodegradation, it does not mean that the contamination problem is solvedproducts of photochemical reactions can be more toxic than parent compounds, e.g., irradiation of naproxen generates possibly genotoxic derivatives (Isidori et al

Omalizumab, a monoclonal antibody against IgE, is an FDA approved treatment for allergic asthma

BAT hypertrophy was also seen in the transgenic global Cebpa knockout mice [15], confirming that C/EBP is not necessary for BAT development