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doi: 10.18632/oncotarget.16783

Interact 204 (2), 6774

132 Although it does not bind ATG5 directly, E2F1 enhances its expression through intermediate regulatory pathways

Larger stones, and stones that fail to pass or cause especially severe pain or obstruction and infection may require more aggressive therapies such as antibiotics, lithotripsy (therapy utilizing ultrasound shock waves to break stones into smaller fragments), or surgery to remove stones (Antonelli 2015)