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Symptoms include: Developmental delays Anemia Loss of appetite Chronic vomiting Weight loss Low brain volume/atrophy Palsy/cramps Apathy Irritability The resulting damage is not always reversible, which is why an adequate B12 intake during pregnancy is critical

The first step in creatine synthesis involves the reversible transfer of the amidino group of arginine to glycine to form guanidinoacetic acid (GAA) and ornithine in a reaction catalysed by the enzyme l-arginine:glycine amidinotransferase in the kidneys

HSP content in the samples was quantified by HPLC, and cumulative release was expressed as a percentage of the total drug loaded [41]

maintain at this dose

Not studied in pregnancy or lactation