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This conflicts with immune checkpoint inhibitor studies reporting closer proximity between tumor and T-cells compared to macrophage and T-cells post-therapy, corresponding to improved therapeutic response (32)

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214 The acid-responsive release of SHK and Chi-Ag NPs from MUC1@ACS NPs cooperatively induced necroptosis in tumor cells by upregulating the expression of receptor-interacting serine/threonine-protein kinase 3 (RIPK3), phosphorylated RIPK3 (p-RIPK3), and tetrameric mixed lineage kinase domain-like protein (MLKL), thereby effectively triggering ICD