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Pernicious anaemia , an autoimmune condition affecting approximately 2% of the UK population over 60 (and about 0.10.2% overall), destroys gastric parietal cells, eliminating intrinsic factor production and severely impairing B12 absorption

For adults over 19, the recommended daily intake (RDI) is 2.4 micrograms (mcg)

It is also important to note that products sold as AOD 9604 are often presented as injectable preparations, though some are marketed in oral or topical forms with unknown absorption and unverified quality

doi: 10.1038/nrdp.2017.34

Even with normal absorption efficiency, low intake creates deficiency risk