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As AIP is a potent competitive PAL inhibitor, the buildup of phenylalanine without increased PAL activity likely explains the observed effects

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Another FIN with a distinct mechanism of action in inducing ferroptosis, RSL3 11 , had similar differential ferroptosis induction in wild-type and IRE1-null MDA-MB-231 cells, suggesting that the effect of IRE1 on ferroptosis sensitivity is not limited to erastin or cystine starvation-induced ferroptosis (Supplementary Fig

Many drugs, including antibiotics, anti-inflammatories, chemotherapeutics, antipsychotics, and others, have demonstrated cytotoxic effects on erythrocytes

Although still in early development, CAAR T therapy may hold particular promise for patients with refractory CLE in the context of systemic involvement