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The objective of this review is to provide a comprehensive and structured synthesis of the immunopathogenesis of HT, integrating established knowledge with emerging research areas including oxidative stress, gut microbiota, and epigenetic modifications, while also summarizing current clinical, diagnostic, and therapeutic perspectives (Fig

Remarkably, the oligodendrocyte replenishment, which includes both OPC proliferation and differentiation, seemed not to be significantly compromised in these transgenic mice, arguing for a direct effect of LIF on differentiated oligodendrocyte survival and myelination (Marriott et al., 2008)

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For FA, the continuous increase in the RD may have a main and greater impact on FA, and such factors like reduction of myelin sheath integrity and fiber density, and edema may ultimately have led to the destruction of microscopic integrity of tissues 37,38 , which was manifested as a continuous decrease in FA from the 4w group to the 6w group 22