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The study supports further clinical adoption of this combination therapy and suggests that it could enhance long-term patient outcomes in CHB management

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An approach to crystallizing proteins by metal-mediated synthetic symmetrization

In this Review, we discuss the mechanisms by which ammonia produces its diverse deleterious effects and their clinical relevance in liver diseases, the importance of measuring ammonia levels for the diagnosis of hepatic encephalopathy, the prognosis of patients with cirrhosis and liver failure, and how our knowledge of inter-organ ammonia metabolism is leading to the development of novel therapeutic approaches