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Citation79,Citation80 Similarly, Kaposis Sarcoma-Associated Herpesvirus (KSHV) mediates host cell glutaminolysis to promote the proliferation of KSHV-transformed cells, and profile analysis of high-throughput RNA sequencing has revealed that the expression levels of many enzymes (such as GLS2 and GOT2) in the glutamine pathway are upregulated by KSHV infection ( Citation8184 As there is competition for glutamine between immune and host cells, viral infection leads to an upregulation of glutamine catabolism in host cells, resulting in a downregulation of glutamine uptake by immune cells and causing changes in the distribution of CD4 + T cell subtypes

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found that targeting cGAS and inhibiting lactylation modifications can promote the transition of microglia from the M1 phenotype to a repair phenotype [110], the addition of lactate has no effect on the expression of A2 astrocytes and only weakens M1 polarization process [57]

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Grazioli and Pugin, 2018)

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By providing a fully structured and reproducible framework, the 3Ts Protocol establishes a standardized platform for the comparative evaluation of emerging regenerative biologics and multimodal strategies in PD

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