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10.1007/s00109-016-1488-y 30 HsuY

Both of these systems require the addition of a source of NADPH

Hypersensitivity reactions have been documented and include skin rashes, itching, and respiratory distress [27]

19 The majority of grade 3 irAEs occur within 8 to 12 weeks of treatment initiation of antiCTLA-4 inhibitors, with the most common being diarrhea and/or colitis (occurring in ~20% of patients), and skin rash usually having the earliest onset (Figure 1)