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Nat Genet (2018) 50(1):1209

& Nordlund, P

See, reactive oxygen species are generated as a by-product when your brain burns fuel for energy

Beyond ETC modulation, hypoxia also controls pyruvate [G] entry into the TCA cycle through HIF-1 induction of lactate dehydrogenase A ( LDHA ) and pyruvate dehydrogenase kinase 1 ( PDK1 ) 102104