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Gut microbiota metabolites can be regarded as mediators of the interaction between gut microbiota and their hosts, and some gut microbiota metabolites have antioxidant, anti-inflammatory, and immune cell-regulating activities, which may be potentially beneficial for the treatment of ITP ( 3.1 Short-chain fatty acids Short-chain fatty acids (SCFAs) are mainly produced by intestinal anaerobes fermenting dietary fiber and absorbed carbohydrates, including acetic acid, propionic acid, and butyric acid, and are inhibitors of histone deacetylase (HDAC) and G-protein-coupled receptors (GPCRs)

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However, treatment strategies are primarily symptomatic highlighting the critical need for a more thorough comprehension of PCOS pathophysiology in order to facilitate focused individualized interventions