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Histopathological features containing vascular and parenchymal changes were graded categorically, according to the scheme of Rubbia-Brandt et al (2010)

2.6 Potential shortcomings in the validity of pain behavioral assessments and animal models of CIPN These are commonly used and well-established animal behavioral assessments to evaluate pain-like behaviors in rodents, which closely resemble the clinical symptoms of CIPN observed in patients

Enhanced understanding of these intricate interactions may reveal novel therapeutic strategies targeting lactylation modifications

& Ihara, M

At higher quantities, mild hypotension and a temporary decrease in concentration have been described in individual observations, likely related to the sedative profile of the compound