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doi: 10.1038/sj.ijir.3900910 179 MatsumotoTKobayashiTKamataK

Pro- and anti-inflammatory eicosanoids in psoriatic arthritis

The gut microbiota also plays a significant role in late-phase oral NR metabolism (3 h post-administration), which is converted to NAM by the enzyme BST1, and then deamidated into NA by microbes, allowing PreissHandler synthesis by capable tissues 127

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Treatment of arthritic rat with DME both at low (3.20 0.25 fold) and high dose (2.23 0.43 fold) reduced the expression of IL-6 significantly as compared with arthritic control group (Fig