Caffeine is absorbed in the small intestine, and then crosses the blood-brain barrier which blocks the absorption of adenosine in our brain cells
Disclosures: Constance Mobley: Nothing to Disclose, Andrea Meinders: Nothing to Disclose, Elizabeth Brombosz: Nothing to Disclose, Enshuo Hsu: Nothing to Disclose, Mozhgon Moaddab: Nothing to Disclose, Ashish Saharia: Nothing to Disclose, Ashton Connor: Nothing to Disclose, Mark Hobeika: Nothing to Disclose, Caroline Simon: Nothing to Disclose, Yee Lee Cheah: Nothing to Disclose, Linda Moore: Nothing to Disclose, Victor Ankoma-Sey: Nothing to Disclose, Chukwuma Egwim: Gilead Sciences: Speaking and Teaching, Tamneet Basra: Nothing to Disclose, Sudha Kodali: SIRTEX: Advisor, Astrazeneca: Advisor, Gilead: Speaking and Teaching, Gilead: Speaking and Teaching, SIRTEX: Advisor, Astrazeneca: Consultant, David Victor: Nothing to Disclose, Rafik Ghobrial: TransMedics: Consultant, Sanofi: Consultant, LyGenesis: Advisory Board Member 696 ARTIFICIAL INTELLIGENCE-DERIVED GRANULAR HISTOLOGICAL MARKERS OF INFLAMMATION AND FIBROSIS ASSOCIATE WITH PROGRESSION IN PATIENTS WITH ALCOHOL-RELATED STEATOHEPATITIS Chady Meroueh 1 Vijay Shah 1 Neel Patel 2 Hanna Pulaski 2 Lara Murray 2 Geetika Singh 2 Liz Thomas 2 Resham Ramkissoon 1 Joseph Ahn 1 Camille Kezer 1 Victoria Kusztos 3 Thomas Smith 1 Jason Hipp 1 Hamid Tizhoosh 1 Peyman Nejat 1 , 1 Mayo Clinic Rochester, 2 PathAI, 3 Mayo Clinic, Rochester Background: There are no current histopathologic markers, which are necessary for adequate treatment, to assess liver-related adverse events (LRE) in Alcohol-associated steatohepatitis (ASH)
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This process may involve the upregulation of the transcription factor Krppel-like factor 6 (KLF6) or the downregulation of PPAR activity (294, 295)
Efek yang tidak diinginkan bisa ringan sampai berat, tergantung dosis
