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For severe cases, treatments might be needed weekly or bi-weekly during the most symptomatic period

Acta, vol

doi: 10.3390/foods14132318 74 FalahFVasieeABehbahaniBAYazdiFTMoradiSMortazaviSAet al

A study revealed that L-methionine supplementation (1.7 g/kg/day, P.O for 8 weeks) was sufficient to produce hyperhomocysteinemia in rats and markedly increased the mean arterial pressure, oxidative stress and mean cardiomyocyte diameter [107]