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Clinical trials in cancer patients with rapalogs, particularly as monotherapies, revealed only modest efficacy, with limited and inconsistent therapeutic responses across tumor types

Chiotis, K

Modifying a drug delivery system with a brain targeting agent has been an effective approach in developing a brain targeting drug delivery system

showed that MMI + antioxidants (83 ug selenomethionine + 17 ug Se yeast + vitamin D) treatment for 6 months improved thyroid activity more effectively than MMI use that alone (20)

31 Oral use of ALC has been shown to improve neuropathic pain in DPN, 43,46,47 with some studies demonstrating its efficacy for antiretroviral toxic neuropathy