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The typical initial treatment for a significant vitamin B12 deficiency involves intramuscular shots 1000 micrograms of the vitamin

It was first isolated and characterised by Professor Predrag Sikiric and his research group at the University of Zagreb in the early 1990s, with the foundational paper published in the Journal of Physiology (Paris) in 1993

doi: 10.1007/s00401-016-1545-1 3 MichalskiJMJanssAJVezinaLGSmithKSBillupsCABurgerPCet al

This is one of the most practical questions and the answer depends entirely on your dose level

Researchers have studied it for autism spectrum disorders, anxiety, depression, and chronic pain