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The questionnaires are designed to be completed by caregivers, but can also be administered by a trained examiner which will be done in the current study
The FDX1-mediated process culminates in profound proteotoxic stress driven by the aggregation of lipoylated mitochondrial proteins and the concomitant destabilization of Fe-S cluster proteins, which together lead to acute mitochondrial failure [3]
This timeline assumes proper sterile technique during reconstitution and consistent cold storage afterward