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CMP25, a synthetic new agent, targets multidrug resistance-associated protein 7 (MRP7/ABCC10)

( i ) Quantification of H2AX foci in cells expressing empty vector or CCNE1 transduced with shRNAs targeting TMLHE alone (shTMLHE) or supplemented with propionylcarnitine or butyrylcarnitine (n = 3 technical replicates representative from 2 independent experiments in each cell line)

Differences in the expression and functions of caspases-4, -5 and -11 are discussed, in addition to mechanisms of their activation, function and regulation, and how these mechanisms may contribute to the pathogenesis of IBD