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and because the ROS are chemically bound to the glutathione molecule, they cant react with cellular machinery to impair their function and cause damage.* Glutathione is thus said to be an antioxidant.* In addition to its potent antioxidant activity, glutathione also supports the other cellular antioxidant systems in the body by offloading excess ROS from them and allowing them to be metabolized safely.* The Complex Relationship Between Glutathione and the Thyroid Glutathiones relationship with the functioning of the thyroid gland is indirect

The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB

doi: 10.1084/jem.189.12.1973 131 MottDYangJBaerCPapavinasasundaramKSassettiCMBeharSM