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2 Energy metabolism in neurons 2.1 Core characteristics and substrate preference of neuronal metabolism Neurons, in comparison to glial cells, maintain a higher energy level due to their continuous need to generate action potentials, synaptic potentials, and neurotransmitters

169 Molecular mediators that drive organ crosstalk Interorgan crosstalk among the kidney, heart, brain, adipose tissue, liver, skeletal muscle, pancreas, and intestine plays a pivotal role in the development of insulin resistance and -cell dysfunction, which are central to the progression of diabetic complications