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These results suggest that L-carnitine supplementation could prevent lenvatinib-induced muscle toxicity without diminishing its antineoplastic activity, although further clinical studies are needed to validate these findings

Mechanistically, these therapeutic effects were dependent on the STING signaling pathway, because PEI-PDA@C-176 NPs only slightly reduced the clinical score in CIA-modeled Sting1 +/ mice without improvements in synovitis (54)

Anbazhagan, M

Aggregation of these proteins and the subsequent reduction of FeS clusters, which are essential cofactors for various cellular processes, including electron transport and enzymatic reactions [102], promote proteotoxic stress and ultimately lead to cell death ( Fig