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Moreover, IRF3-mediated production of type I IFN was suggested to be the driving force for the observed STAT1 phosphorylation and expression of innate immune response genes such as IFIT1 in breast cancer type 2 susceptibility protein (BRCA2)-deficient H1299 cells

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Ferroptosis-based tumor vaccine As previously mentioned, early ferroptotic cancer cells possess immunogenicity, which can promote the maturation and activation of BMDCs in immunocompetent mice, thereby enhancing T cell antitumor immunity [43]

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The first sample, the control, was not modified, while the two remaining samples were modified by incorporating in them 2% of the compound of Example 1, HSS and 4% of octocrylene, respectively