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En la siguiente imagen se ilustra el mecanismo propuesto para el desarrollo de osteopenias mediado por el receptor Pregnano X, relacionado con la vitamina D

Ascorbate requirements of smokers based on intake and serum concentrations show that smokers may require as much as three times the dose of ascorbate than nonsmokers to avoid risk of efficiency [3032, 34]

Unverified sources may contain degraded peptide fragments, incorrect amino acid sequences, or insufficient active compound, meaning stated dose doesn't match pharmacologically active dose