aeruginosa to the mucoid phenotype worsens prognosis although it is more common in patients with CF.74,75 Although there are no studies to guide practice following the first isolation, an attempt to eradicate seems pragmatic for what it should be treated aggressively regardless of the patient's clinical signs or symptoms in order to eliminate the microorganism from the sputum as it is very difficult to do so once chronic colonization is established.3,4 In non-CF BE the strategy proposed for eradication is oral ciprofloxacin for 3 weeks and if it fails, the same protocol as for CF is recommended (nebulized antibiotic: tobramycin, sodium colistimethate or aztreonam lysine) plus oral ciprofloxacin for 3 weeks, followed by inhaled antibiotics for 312 months.4,60,76 An alternative would be an association of 2 anti-Pseudomonas intravenous antibiotics for 1421 days, followed by an inhaled antibiotic for 312 months.4,60,76 As was stated above, an antibiogram is essential for guiding treatment although it is recognized that in vitro sensitivity does not always correlate with therapeutic response
It also helps to boost the production of other antioxidants such as vitamin C and E
Superoxide measurements in liver and kidney by electron paramagnetic resonance (EPR) spectroscopy Mitochondrial superoxide in liver and kidney tissue was measured by EPR spectroscopy using a mitochondrial targeted probe, 1-hydroxy-4-[2-triphenylphosphonio)-acetamido]-2,2,6,6-tetramethylpiperidine,1-Hydroxy-2,2,6,6-tetramethyl-4-[2-(triphenylphosphonio)acetamido] piperidinium dichloride (mito-TEMPO-H) (Enzo Life Sciences, Farmingdale, NY) 24,25
Glutathione vials (compounded in licensed U.S
Selenoproteins protect cell membranes from ROS-induced damage and keep blood platelets in a healthy state, both factors are responsible for the healthy functioning of the cardiovascular system
