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Each puncture through a rubber stopper dulls the needle tip and introduces microscopic rubber particles into your solutionthese particles can trigger immune responses in research models and create confounding variables in your data

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These washout periods, which have been updated slightly since the 2022 List documents were published on 30 September to incorporate the latest scientific information, are highlighted in the revised version of the Summary of Major Modifications and Explanatory Note, and are based on the use of these medications according to the maximum manufacturers licensed doses

subsequent evaluations may provide more information