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Pediatr Endocrinol Rev

Diagnostic criteria and measurement techniques of sarcopenia: a critical evaluation of the up-to-date evidence

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elegans , where HLH-30 (ortholog of TFEB) regulates the expression of lysosomal triglyceride lipases ( Tfeb in mice (TFEB-Tg mice) leads to an improvement of glucose tolerance, insulin sensitivity, and weight gain in mice fed with high-fat diet and, importantly, to a lean phenotype that is abolished in an Atg7 -deficient background, genetically demonstrating the epistasis of TFEB and autophagy (Settembre et al., 2013)