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ndufs2 -/- larvae showed increased liver Oil Red O staining (where increased liver staining is measured as decreased light intensity) indicative of increased lipids, consistent with findings in other PMD zebrafish models

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These metabolic changes align with significant disruptions in amino acid metabolism, along with disturbances in glutathione biosynthesis and spermidine/spermine metabolism in male patients with PARK2 , PINK1 , or PARK7 mutations, as indicated by pathway enrichment analysis

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