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If the vitamin B12 is ingested in its protein bound form, then it must first undergo a proteolytic cleavage in the stomach or duodenum where it will bind to an R-binder and then enter into the duodenum for further cleavage.1,2,8 This proteolytic cleavage is mostly dependent on the functional activity of pepsin

Now, we have to do some arithmetic

However, this inference depends on oral bioavailability data in humans, which does not currently exist

At first every

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