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PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery

The priming phase is initiated when DAMPs or PAMPs engage receptors such as toll-like receptors (TLRs) or cytokine receptors, triggering the NF-B pathway to increase mRNA levels of NLRP3, pro-IL-1, and pro-IL-18 (Zahid et al., 2019)