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In the pathogenesis of type 2 diabetes, aberrant immune cell activation and the accompanying chronic inflammatory milieu are consequences of diabetes, which in turn lead to pathologic damage and disease progression

Revised: June 2007 (9th version)

The signs of uremia in cats include lethargy, depression, anorexia, and vomiting due to gastritis

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Systemic Considerations (Experimental Observations Only) Some preclinical investigations report changes in: inflammatory markers oxidative stress pathways vascular responses However, these findings are model-dependent and do not define a consistent systemic safety profile