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Upadhyay N, et al

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Monitoring PpIX biosynthesis in vivo by real-time FL/PA duplex imaging As oxidative stress is a key to the synergistic effect of IIT and 5-ALA-PDT for enhanced therapeutic efficacy 37,47,48 , we explored the metabolic dynamics of PpIX and O 2 generation to validate the feasibility for PpIX synthesis regulation and optimizing treatment parameters in vivo