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Microglial activation is a hallmark of AD, initially serving a protective role but becoming detrimental upon chronic stimulation (Li et al., 2021)

New England Journal of Medicine+2PMC+2 Other gut peptides (e.g., linaclotide)

The outcome of this competition depends from the Cu(II)-binding affinities and concentrations of HSA, CuHSA and His according to the following simplified reaction scheme: HSA and His are present in the blood serum at average 650 M and 75 M concentration respectively 22,42,43,44

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