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Description

Teikyo Med

78 LeeK.-W.MaL.YanX.LiuB.ZhangX.-K.CohenP

5 Nanotechnology-enabled immunotherapy: reprogramming the tumor microenvironment PC presents one of the most formidable immunosuppressive tumor microenvironments (TME) in oncology, characterized by dense desmoplastic stroma, profound hypoxia, limited CD8 + T cell infiltration, and abundant immunosuppressive myeloid populations including tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs)