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Calcif Tissue Int 95:349361

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These processes do not act in isolation but instead converge and amplify one another in a complex interplay that underlies neuronal vulnerability and death

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In addition, it has been shown that 5-azacitidine (5-aza), a DNA hypomethylating agent, has synergistic effects when given with a topoisomerase 1 inhibitor, irinotecan, for the treatment of CRC [99], further complicating the role of DNA methylation in CRC