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The evidence base requires appropriate clinical trials, with additional endpoints including clinical symptoms of patients and additional biochemical parameters beyond plasma B12 levels alone before these alternative routes can be recommended with confidence in clinical guidelines

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When you add tyrosine to the N-terminus of the 176-191 fragment, the numbering technically shifts making AOD-9604 more accurately described as Tyr-hGH 177-191

The decision is about which format is appropriate for the scale and design of your research programme

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