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These changes contribute to neuroinflammation, bloodbrain barrier (BBB) dysfunction, microglial activation, and neurotransmitter imbalances

Fucidin cream (fusidic acid) was selected as a standard treatment to reflect current clinical practice in chronic wound management, although its primary action is antibacterial rather than anti-inflammatory or antioxidant

10.1038/s41537-017-0013-9 201

Kunwar A, Barik A, Mishra B, Rathinasamy K, Pandey R, Priyadarsini KI (2008) Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

Unlike conventional nave T cells, aged CD8+ TVM cells exhibit marked functional decline, adopting a SASP phenotype and accumulating DNA damage markers like H2AX (Quinn et al, 2018)