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Neurochem Res 37:16811689 Rose S, Melnyk S, Pavliv O, Bai S, Nick T, Frye R, James S (2012) Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

In contrast, oxidized forms of sulfur-containing amino acids (e.g., methionine sulfoxide, cystine), as well as of arginine, increased (Figure 4A)

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published in Hormone Research, oral AOD-9604 given to obese Zucker rats for 19 days reduced body weight gain by more than 50% compared to controls, with no adverse effect on insulin sensitivity confirmed by euglycemic clamp testing

Caspase-dependent protein degradation is also attenuated by IGF/PI3K/Akt signaling, whereas evidence for an effect on calpain-dependent protein degradation is inconclusive