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The current understanding of FLIO requires further investigation through molecular imaging and pharmacological validation to accurately link fluorescence lifetimes to specific retinal molecules in vivo

In accordance with another respect of the present invention there are provided analogic peptides in amide or carboxy terminated form at C terminus, having the structural formulas hereinabove described, and wherein at least one and at most 7 amino acid residues in region 1-15 are omitted and at least one of the remaining amino acid residues can be substitued according to described schema of substitution in table I

Genetic and pharmacological inhibition of SLC7A11 in CRC stem cells significantly attenuates their viability in vitro and in vivo in comparison to CRCs (123, 124)

These findings also support observations made by other authors, who have shown that PEF contributes to the release of autolytic enzymes located in the lysosomes of the cytoplasm ( FIGURE 7 Figure 7 also shows that once the supernatant was removed after 24 h of incubation, enzymatic activity was still observed in the media in which the biomass had been re-suspended