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On the other hand, AGAT and GAMT deficient patients who have reduced ability for de novo synthesis of creatine, can be successfully treated with oral creatine supplementation, although very high doses of creatine are used, and the replenishment of cerebral creatine takes months (Ganesan et al., 1997)

Other environmental exposures, which have been related to DNA methylation, such as exposure to tobacco smoke [13-17] and air pollution [18], are out of the focus of the present review, as tobacco smoke and air pollution are mixtures of different types of chemicals rather than individual groups of compounds

10.1021/np2009626 173 OjhaR

Tenora et al., 2019

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