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(3)Weighted mode method, a sensitivity analysis used to detect and adjust for pleiotropy as well [23]

Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury

Mitochondrial glutathione, a key survival antioxidant Antioxid Redox Signal

Selenium plays a major role in spermatogenesis and sperm maturation [141] and can protect sperm from ROS-induced DNA damage

Acknowledgements This study was performed with the support of the National Natural Science Foundation of China (82002339, 81820108020), Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System (BJ1-9000-22-4002)