glutathione astrocyte system xc Proposed roles of xc⁻. Three main roles have been proposed for Thinking Outside the Cleft to

Thinking Outside the Cleft to Understand Synaptic Activity: Contribution of the Cystine Glutamate Antiporter (System xc) to Normal and Pathological Glutamatergic Signaling ScienceDirect Cystine Glutamate Exchange Modulates Glutathione Supply for Neuroprotection from Oxidative Stress and Cell Proliferation Journal of Neuroscience Molecular basis for redox control by the human cystine glutamate antiporter system xc Nature Communications Protein Glutathionylation and Glutaredoxin in Neurodegenerative Diseases Encyclopedia MDPI Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes ScienceDirect

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