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The training process entails additional time and labor costs, which may be unattainable in resource-limited settings

It is also a potent detoxifier and a very effective protector of our immune system, thus keeping our skin and organs in perfect condition

The crucial role of NF-B and NO in the adverse effects seen with DOX treatment is well documented in several studies 104,105

Combined, these put the median Kollam melasma patient at greater pigment burden and faster relapse risk than European or even non-coastal Indian reference data

Moreover, there is evidence that both, oxidative stress and mitochondrial damage are associated with changes in GSH homeostasis